An aging comic icon, Jackie Burke (Robert De Niro) has seen better days. Despite his efforts to reinvent himself and his comic genius, the audience only wants to know him as the former television character he once played. Already a strain on his younger brother (Danny Devito) and his wife (Patti LuPone), Jackie is forced to serve out a sentence doing community service for accosting an audience member. While there, he meets Harmony (Leslie Mann), the daughter of a sleazy Florida real estate mogul (Harvey Keitel), and the two find inspiration in one another resulting in surprising consequences. Through the alchemy of their unlikely friendship, Harmony and Jackie overcome their own emotional damage and emerge as better people.