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Cast- Avatar: The Way of Water (2022) as Kiri
- Call Jane (2022) as Virginia
- Master Gardener (2022) as Mrs. Haverhill
- Ghostbusters: Afterlife (2021) as Dana Barrett
- Good House ,The (2021) as Hildy Good
- My Salinger Year (2020) as Margaret
- Assignment, The (2016) as Dr. Rachel Kay
- Ghostbusters (2016) as ?
- Monster Calls, A (2016) as Grandma
- Chappie (2015) as ?
- Exodus: Gods and Kings (2014) as Tuya
- Cold Light of Day, The (2012) as ?
- Rampart (2012) as Joan Confrey
- Red Lights (2012) as Margaret Matheson
- Vamps (2012) as Cisserus
- Abduction (2011) as Dr. Bennett
- Cedar Rapids (2011) as Macy Vanderhei
- Paul (2011) as Tara
- Crazy on the Outside (2010) as Vicky
- You Again (2010) as Aunt Ramona
- Avatar (2009) as Dr. Grace Augustine
- Baby Mama (2008) as Chaffee Bicknell
- Tale of Despereaux, The (2008) as The Narrator (voice)
- Vantage Point (2008) as Rex
- Happily N'Ever After (2007) as Frieda (voice)
- Infamous (2006) as Babe Paley
- Snow Cake (2006) as Linda Freeman
- TV Set, The (2006) as Lenny
- Imaginary Heroes (2004) as Sandy Travis
- Village, The (2004) as Alice Hunt
- Holes (2003) as The Warden
- Guys, The (2002) as Joan
- Tadpole (2002) as Eve
- Heartbreakers (2001) as Max
- Company Man (2000) as Daisy Quimp
- Galaxy Quest (2000) as Gwen DeMarco / Lieutenant Tawny Madison
- Map of the World, A (1999) as Alice Goodwin
- Gorillas In The Mist (1998) as Dian Fossey
- Alien: Resurrection (1997) as Lieutenant Ellen L. Ripley Clone #8 / #7
- Alien: Resurrection (1997) as Lieutenant Ellen L. Ripley Clone #8/#7
- Ice Storm, The (1997) as Janey Carver
- Snow White: A Tale Of Terror (1997) as Claudia Hoffman
- Copycat (1995) as Helen Hudson
- Jeffrey (1995) as Debra Moorhouse
- Death And The Maiden (1994) as Paulina Escobar
- Dave (1993) as Ellen Mitchell
- 1492: Conquest of Paradise (1992) as Queen Isabel
- Alien 3 (1992) as Ellen Ripley
- Ghostbusters II (1989) as Dana Barrett
- Working Girl (1988) as Katherine Parker
- Aliens (1986) as Lieutenant Ellen Ripley
- Ghostbusters (1984) as Dana Barrett / Zuul (the Gate Keeper)
- Deal of the Century (1983) as Catherine DeVoto
- Year of Living Dangerously, The (1982) as Jill Bryant
- Alien (1979) as Warrant Officer Lieutenant Ellen L. Ripley
- Alien (1979) as Ripley
- Annie Hall (1977) as Alvy's Date Outside Theatre
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