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Cast- King of Kings, The (2025) as Catherine Dickens (voice)
- The Old Guard 2 (2025) as Discord
- Oh Canada (2024) as Emma
- Kill Room, The (2023) as Patrice
- Red, White & Royal Blue (2023) as Ellen Claremont
- War with Grandpa, The (2020) as Sally
- Brits Are Coming, The (2018) as Harriet Fox
- Con Is On, The (2018) as Harriet Fox
- Down a Dark Hall (2018) as ?
- House That Jack Built, The (2018) as Lady 1
- Adam Jones (2015) as Simone
- Burnt (2015) as Simone
- Movie 43 (2013) as Lois Lane
- Nymphomaniac (2013) as ?
- Bel Ami (2012) as Madeleine Forestier
- Playing for Keeps (2012) as Patti
- Savages (2012) as Paqu
- Ceremony (2010) as Zoe
- Percy Jackson & the Olympians: The Lightning Thief (2010) as Medusa
- Motherhood (2009) as Eliza Welsh
- Accidental Husband, The (2008) as Dr. Emma Lloyd
- Life Before Her Eyes (2008) as Diana
- My Super Ex-Girlfriend (2006) as Jenny Johnson/G-girl
- Be Cool (2005) as Edie Athens
- Prime (2005) as Rafi Gardet
- Producers, The (2005) as Ulla
- Kill Bill: Vol. 2 (2004) as The Bride (Black Mamba)
- Kill Bill: Volume 1 (2003) as The Bride (a.k.a. Black Mamba)
- Paycheck (2003) as Rachel
- Hysterical Blindness (2002) as Debby Miller
- Chelsea Walls (2001) as Grace
- Tape (2001) as Amy
- Golden Bowl, The (2000) as Charlotte Stant
- Sweet And Lowdown (1999) as Blanche
- Avengers, The (1998) as Emma Peel
- Batman & Robin (1997) as Poison Ivy / Dr. Pamela Isley
- Gattaca (1997) as Irene Cassini
- Beautiful Girls (1996) as Andera
- Truth About Cats And Dogs, The (1996) as Noelle Slusarsky
- Month By The Lake, A (1995) as Miss Beaumont
- Pulp Fiction (1994) as Mia Wallace
- Even Cowgirls Get The Blues (1993) as Sissy Hankshaw
- Dangerous Liaisons (1988) as Cecile de Volanges
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