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Cast- Reptile (2023) as Tom Nichols
- French Dispatch, The (2021) as Moses Rosenthaler
- No Sudden Move (2021) as Ronald Russo
- Dora the Explorer (2019) as Swiper (voice)
- Avengers: Infinity War (2018) as The Collector
- Sicario: Day of the Soldado (2018) as Alejandro Gillick
- Song to Song (2017) as ?
- Star Wars: The Last Jedi (2017) as ?
- Weightless (2016) as ?
- Little Prince, The (2015) as The Snake (voice)
- Perfect Day, A (2015) as Mambrú
- Sicario (2015) as Alejandro
- Escobar: Paradise Lost (2014) as Pablo Escobar
- Guardians of the Galaxy (2014) as The Collector
- Inherent Vice (2014) as Sauncho Smilax
- Jimmy P (2013) as Jimmy Picard
- Savages (2012) as Lado
- Somewhere (2010) as Celebrity
- Wolfman, The (2010) as Lawrence Talbot
- Che: Part One (2008) as Ernesto Che Guevara
- Che: Part Two (2008) as Ernesto 'Che' Guevara de la Serna
- Things We Lost in the Fire (2007) as Jerry Sunborne
- Sin City (2005) as Jack Rafferty
- Rum Diary, The (2004) as Bob Sala
- 21 Grams (2003) as Jack
- Chaos (2003) as .
- Hunted, The (2002) as Aaron Hallam
- Pledge, The (2001) as Toby Jay Wadenah
- Traffic (2000) as Javier Rodriguez
- Way Of The Gun, The (2000) as Longbaugh
- Snatch (1999) as Franky Four Fingers
- Fear And Loathing In Las Vegas (1998) as Oscar Zeta Acosta / Dr. Gonzo
- Excess Baggage (1997) as Vincent Roche
- Basquiat (1996) as Benny Dalmau
- Fan, The (1996) as Juan Primo
- Usual Suspects, The (1995) as Fred Fenster
- License to Kill (1989) as Dario
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